N1-methylpseudouridylation of mRNA causes +1 ribosomal frameshifting | NVAX Message Board Posts


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Msg  217384 of 220405  at  12/8/2023 3:40:37 PM  by

Bluehill


N1-methylpseudouridylation of mRNA causes +1 ribosomal frameshifting

https://www.nature.com/articles/s41586-023-06800-3

Here we demonstrate that incorporation of N1-methylpseudouridine into mRNA results in +1 ribosomal frameshifting in vitro and that cellular immunity in mice and humans to +1 frameshifted products from BNT162b2 vaccine mRNA translation occurs after vaccination.


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Msg # Subject Author Recs Date Posted
217393 Re: N1-methylpseudouridylation of mRNA causes +1 ribosomal frameshifting Booooyaaaah 0 12/9/2023 4:28:08 AM




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