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The following message was updated on 6/5/2023 8:54:22 AM.
They won't let me post this on the wingnut board OT OT
In this manuscript, we conducted an exploratory analysis to evaluate the effect of brensocatib on PR3 and CatG activity in sputum, and NE activity in white blood cell (WBC) extracts, which were not previously reported in the phase 2b trial in NCFBE [13]. We also compared the extent of reduction of NSP activity in both WBC extracts and sputum compartments and identified correlations in all three NSP activities at baseline and on treatment. These data may inform on the effect of a reversible DPP-1 inhibitor like brensocatib on the relevant pharmacodynamic (PD) biomarkers and their contribution to morbidity in NCFBE.