I understand, but from what I hear you are confusing safety and convenience. Otezla's problem (other than lowest efficacy in the industry) is tolerability, not safety. To a person, every derm I've talked to says Otezla is about as safe as anything they have ever had.
On the other hand, we have a medication guide that sure looks like the one JAKS give out. Included in it are: serious infections, viral reactivations(herpes zoster), tuberculosis, Rhabdomyolysis, malignancies including lymphomas, liver enzyme elevations, lipid elevations, and concerns over live vaccinations. Those are safety concerns, not tolerability concerns.
We work better, have more convenient dosing and are more tolerable but the data do not show at all that we are safer. Not where close.