Death knell for NTLA's potential CRISPR treatment for HAE: Excepts from two new studies published in Nature Communications in late October 2022: Using the new method, the researchers tested 8,000 potential off-targets for 110 CRISPR guide RNAs in the process of being translated into human medicine. "We found far more off-targets than we would have been able to using existing methods," Gorodkin explains. Furthermore, 37 of these off-targets are located in cancer-related genes, which increases the risk that developing drugs will become harder or even impossible. In addition, unintended cuts in these genes may even lead to cancer as a possible side-effect. phys.org/news/2022-10-break...