Volume 40,
Issue 2, 2023,
pp. 43-82
DOI: 10.1615/CritRevTherDrugCarrierSyst.2022041853
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Vasanti Suvarna
Department of Pharmaceutical Chemistry & Quality Assurance,
SVKM's Dr. Bhanuben Nanavati College of Pharmacy, Vile Parle (W), Mumbai
400056, Maharashtra, India
Niserga Sawant
C.U. Shah College of Pharmacy, SNDT Women's University, Santacruz (W), Mumbai 400049, Maharashtra, India
Namita Desai
Department of Pharmaceutics, C. U. Shah College of Pharmacy, SNDT
Women's University, Santacruz (W), Mumbai - 400049, Maharashtra, India
ABSTRACT
Unmodified nanocarriers used in the chemotherapy of cancers and
various infectious diseases exhibit prolonged blood circulation time,
prevent enzymatic degradation and increase chemical stability of
encapsulated therapeutics. However, off-target effect and lack of
specificity associated with unmodified nanoparticles (NPs) limit their
applications in the health care system. Mannose (Man) receptors with
significant overexpression on antigen-presenting cells and macrophages
are among the most admired targets for cancer and anti-infective
therapeutics. Therefore, development of Man functionalized nanocarriers
targeting Man receptors, for target specific drug delivery in the
chemotherapy have been extensively studied.
Present review expounds
diverse Man-conjugated NPs with their potential for targeted drug
delivery, improved biodistribution profiles and localization.
Additionally, the review gives detailed account of the interactions of
mannosylated NPs with various biological systems and their
characterization not discussed in earlier published reports is
discussed.
